Effect of epinephrine on the absorption of lidocaine following application to the oral mucosa in rats

Abstract Background We investigated the role of epinephrine in prolonging localization lidocaine on oral mucosa and inhibiting its absorption blood rats. Methods used 7–8-week-old pathogen-free Wistar male rats (n = 128) for our study. divided them into control group administered with 14 C-labeled hydrochloride gel only study epinephrine. The medications were palatal amount mucosa, palatine bone, serum was measured by radioactivity using a liquid scintillation counter observed autoradiograms. Results Initially, there no significant difference levels between groups (751.9 ± 133.8 vs. 669.8 101.6 ng/mg [2 min]). After 4 min, values significantly lower (1040.0 142.8 701.2 109.0 [20 40 level became higher (586.8 112.4 1131.3 155.2 [40 Similar results bone serum. Conclusion Epinephrine prolonged applied to inhibited bloodstream Clinical studies are required evaluate use epinephrine-containing topical anesthetics mucosa.